Chemomechanical Simulation of Microtubule Dynamics With Explicit Lateral Bond Dynamics

We introduce and parameterize a chemomechanical model of microtubule dynamics on the dimer level, which is based allosteric tubulin includes attachment, detachment hydrolysis dimers as well stretching lateral bonds, bending at longitudinal junctions, possibility bond rupture formation. The computationally efficient such that we reach sufficiently long simulation times to observe repeated catastrophe rescue events realistic concentrations rates, allows us deduce rates. also gain insight into microscopic features GTP-tubulin cap structure structural triggering catastrophes rescues. Dilution simulations show qualitative agreement with experiments. explore consequences possible feedback mechanical forces onto process structure.